Oral Controlled/Sustained rel RX

Extended release

 

vs

 

Delayed release

Extended release= drug available over an extended period of time

 

 

 

Delayed release= drug released later time (not immediately)

Main matrix system used
wax matrix system
Klor-Con, Klotix,Slow K tablets (matrix system)

KCl 

slow release = less GI irritation

Prevents high local conc of K+

Paxil CR

Swelling/Eroding matrix

 

hydrates and swells over time to inc SA

proquin xr

ciprofloxacin HCl

 

gastroretentive system(drug release controlled in Stomach)

 

matrix controlled release

 

-drug release in stomach allows max abs in intestine

Dexedrine Spansules (Dextroamphetamine)

Spansules made by Glaxo-Smith-Kline

 

Coated Rx(prolong drug release)

 

SODAS????

Spheroidal Oral Drug Absorption System (Elan)

 

uniform, 1-2 mm beads of drug plus excipients are surrounded by layers of soluble and insoluble polymers.

 

EX: VERELAN

 

 

CODAS

Chronotherapeutic Oral Drug Absorption System

 

enables delay in the release of the drug

 

Verelan PM = used chronotherapeutically, whereby the drug is not released until 4 to 5 hours after ingestion

Membrane-Coated Pellets

-Kadian (morphine sulfate) ER capsules=

 

[PEG dissolves quick,enteric polymer dissolves at high pH, allowing more drug to diffuse out in GI]

 

EMbeda

EMBEDA (morphine sulfate and naltrexone HCl) ER caps

pellets of drug beads 

 

 membrane coated pellet

 

sequestered coating>surrounded by Rx>surrounded polymer coating

IPDAS

Intestinal Protective Drug Absorption System

 

Membrane-Matrix Hybrid-beads wi semipermeable membrane

 

Osmotically Controlled Systems

-semipermeable membrane & osmotic pressure

 

-GITS  GI systems (Alza)

 

-two osmotically active compartments

-from laser drilled hole

 

ex: Procardia-XL,CONCERTA,COVERA

Concerta (methylphenidate HCl)[2 conc inside]

 

variation of GITS

 

 

Covera HS (drug taken at HS will start to work in a.m)

intervening layer

[product shud end up in stool]

Ion Exchange sys

Delsym Suspension (Dextromethorphan Polistirex)- q12 h vs q 4 to 8h

 

tussionex

 

pennkinetic sys

(ion-exchange resin coated with non dissolving polymer)

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