Oral Controlled/Sustained rel RX

Extended release




Delayed release

Extended release= drug available over an extended period of time




Delayed release= drug released later time (not immediately)

Main matrix system used
wax matrix system
Klor-Con, Klotix,Slow K tablets (matrix system)


slow release = less GI irritation

Prevents high local conc of K+

Paxil CR

Swelling/Eroding matrix


hydrates and swells over time to inc SA

proquin xr

ciprofloxacin HCl


gastroretentive system(drug release controlled in Stomach)


matrix controlled release


-drug release in stomach allows max abs in intestine

Dexedrine Spansules (Dextroamphetamine)

Spansules made by Glaxo-Smith-Kline


Coated Rx(prolong drug release)



Spheroidal Oral Drug Absorption System (Elan)


uniform, 1-2 mm beads of drug plus excipients are surrounded by layers of soluble and insoluble polymers.






Chronotherapeutic Oral Drug Absorption System


enables delay in the release of the drug


Verelan PM = used chronotherapeutically, whereby the drug is not released until 4 to 5 hours after ingestion

Membrane-Coated Pellets

-Kadian (morphine sulfate) ER capsules=


[PEG dissolves quick,enteric polymer dissolves at high pH, allowing more drug to diffuse out in GI]



EMBEDA (morphine sulfate and naltrexone HCl) ER caps

pellets of drug beads 


 membrane coated pellet


sequestered coating>surrounded by Rx>surrounded polymer coating


Intestinal Protective Drug Absorption System


Membrane-Matrix Hybrid-beads wi semipermeable membrane


Osmotically Controlled Systems

-semipermeable membrane & osmotic pressure


-GITS  GI systems (Alza)


-two osmotically active compartments

-from laser drilled hole



Concerta (methylphenidate HCl)[2 conc inside]


variation of GITS



Covera HS (drug taken at HS will start to work in a.m)

intervening layer

[product shud end up in stool]

Ion Exchange sys

Delsym Suspension (Dextromethorphan Polistirex)- q12 h vs q 4 to 8h




pennkinetic sys

(ion-exchange resin coated with non dissolving polymer)

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