Nitrogenous and Iron Compounds/Renal System

Non Protein Nitrogen
Process that occurs before reaching the kidneys
Processes that occur in the kidney
Process that occurs after the kidneys
Renal Clearance
The volume of plasma from which the kidneys can remove all of a given substance in a certain time period, usually one minute.
Primary nitrogenous compound which builds up in the blood
Waste product of protein metabolism normally removed from the blood in the kidneys
The sole site of urea formation
A nitrogenous compound whose production is fairly stable; therefore more indicative of kidney failure
Formed in increased amounts as protein breaks down
Uric Acid
Primary waste product or purine metabolism
Gout, Increased catabolism, Renal disease
Three major disease states associated with elevated plasma uric acid
While treated as a Non Protein Nitrogen, is primarily excreted by the liver and NOT the kidneys
Liver disease
The most common cause of abnormal ammonia metabolism
Provides an indication of renal performance
A significant increase in the plasma concentrations of urea, in kidney insufficiency
Blood Urea Nitrogen
Measures the amount of the nitrogen found in blood area. This nitrogen is attributed to urea, which is constantly being produced from the catabolism of amino acids / oldest method
Coupled Enzymatic Analysis
Methodology for measuring ammonia
Methodology for measuring creatinine
Methodology for measuring Uric Acid
The volume of plasma from which the kidney can remove all of a given substance in a certain period of time, usually one minute
Functions of Iron
Binds reversably with oxygen
Aids in electron transport
Oxygen carrying protein in red blood cells.
Largest concentration of iron in the body.
Oxygen binding protein of striated and cardiac muscles.
Tissue Iron
approx 8 mg
certain cellulat enzymes and coenzymes
peroxidases and cytochromes
all nucleated cells in the body
Labile pool
iron in transition from one point to another
80 mg
Transport of iron
accomplished by protein, apotransferrin
Storage of Iron
Males 800 mg
Females 0-200 mg
Daily requirements of iron
10-15 mg/day, mostly from meat
varied depending on age, fender, psysiological status
Iron storage compartments
Liver, Bone Marrow, Spleen and other tissues
major iron storage compound
Found in cells of the liver, spleen, bone marroe
How the iron balance is regulated
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