Neurochemistry!

Acetylcholine MADE FROM: Dietary choline Acetylcholine MECHANISM: Excitatory & Inhibitory Acetylcholine LOCATION: Autonomic Nervous System Motor Neurons CNS Acetylcholine FUNCTION: Visceral function Movement Memory Acetylcholine DISORDER: Myasthenia gravis Alzheimer’s Disease (too little ACh) –> Plaques & Tangles! Beta-amyloid Plaques Neurofibrillary Tangles Glutamate MADE FROM: Amino Acid Glutamate MECHANISM: Excitatory Glutamate LOCATION: Most abundant Neurotransmitter in […]

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Neuro Chemistry

neurochemistry focuses on the basic chemical composition and processes of the nervous system neuropharmacology is the study of compounds that selectively affect the nervous system EP or adrenaline chemical messenger that acts as a hormone to mobilize the body for fight or flight during times of stress and as a NT in the CNS NE […]

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Neurochemistry

Acetylcholine 1. Pontomesencephalic Tegmentum 2. Basal Forebrain (Nucleus Basalis of Meynert) and Medial Septum Norepinephrine 1. Locus Ceruleus in pons 2. Lateral Tegmentum of pons 3. Lateral/ventrolateral tegmentum of medulla Serotonin 1. Raphe nucleus of brainstem 2. Rostral Raphe: dorsal raphe-> ascending projections 3. Caudal Raphe: Raphe pallidus and raphe magnus-> descending projections Histamine Tuberomammillary […]

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PCOL Exam 2: Neurotransmission & Basic Neurochemistry

GABA meaning Gamma amino-butyric acid Major inhibitory transmitter in brain GABA synthesis Enzyme=glutamic acid decarboxylase COOH removed from glutamic acid to make GABA GABA inactivation Reuptake=major means of inactivation Broken down by GABA-transaminase Catabolism blocked by gamma vinyl GABA GABA receptor subtypes 2 receptor subtypes A=ligand-gated ion channel B=GPCR GABA-A mechanism increase in membrane permeability […]

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Anxiety disorders:Neurobiology, neurochemistry and treatment

What is the role of the amygdala? emotions, memory, decision making The amygdala receives inputs from which areas of the brain? sensory cortex and sensory thalamus (and hippocampus) The amygdala sends outputs to which areas involved in fear response? (3) lateral hypothalamus = sympathetic activation; tachycardia, pupil dilation, blood pressure elevation ventral tegmental area: locus […]

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Basic Neurochemistry

neurotransmitter characteristics 1) vesicle storage 2) Ca dependent release 3) interaction with postsynaptic target *interaction with target should illicit uniform response neuromodulator almost meets all of criteria of neurotransmitter but some discrepancy have slow and long lasting effects forming vesicle in presynaptic terminal ex. choline taken in through membrane, form ACh, then put in vesicle […]

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Neurochemistry

Dendrites – Multiple per cell forming arbors, non/spiny; clustered near soma; highly plastic – Organise, respond, synthesise inputs to neuron DNA nucleus contains the DNA (DNA the same in every nucleus).. Chromatin determines cell expression ie. what gene is what Process of DNA –> protein DNA transcribed to mRNA mRNA moves to cytoplasm in the […]

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Neurochemistry Concepts

what are the three protective features of the brain? the blood brain barrier, the bony skull, and the cerebral spinal fluid, which provides cushioning for the brain what is an example of a leak channel potassium leak channels, which allow potassium out of the cell with the concentration gradient and help maintain the membrane potential […]

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neurochemistry

synthesis of Ach Acetyl CoA + choline via choline acetyltransferase (ChAT) Elimination of Ach via acetylcholinesterase to choline and acetate (choline is re-used) synthesis of dopamine tyrosine –> DOPA via tyrosine hydroxylase –> dopamine by decarbosylase elimination of dopamine via transport into presynaptic element and then into the surrounding glial cells. within the glia the […]

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