Astorvastin (Lipitor)

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Astorvastin (Lipitor) Usual Dose
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PO, 10-20mg/once a day
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Astorvastin (Lipitor) Classifications: (Therapeutic, Pharmaceutical, Indications)
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T: Lipid-lowering agent P: HMG-CoA Reductase Inhibitors/Statins I: Prevention of coronary disease.
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Astorvastin (Lipitor) Action & Therapeutic Effects
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A: Inhibits HMG-CoA reductase, an enzyme responsible for the beginning synthesis of cholesterol TE: Lowering total/LDL cholesterol and triglycerides. Reduction of lipids/cholesterol to reduce risk of MI. Slows progression of coronary atherosclerosis.
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Astorvastin (Lipitor) Adverse Reactions, Side Effects, and Contradictions
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AR: Rhabdomyolysis (breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream), Angioneurotic edema (Hypersensitivity Reaction) SE: Headache, abdominal cramps, constipation, diarrhea, flatus, heartburn C: Hypersensitivity, Active Liver Disease, Potential for Fetal Abnormalities, May appear in breast milk
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Astorvastin (Lipitor) Nursing Implications
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Obtain diet history, especially with fat consumption; Evaluate cholesterol and triglyceride levels; Monitor liver function tests; If patient develops muscle tenderness, CPK levels should be monitored.
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Astorvastin (Lipitor) Evaluation
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Evaluate cholesterol and triglyceride levels; Monitor liver function tests; Decrease in LDL and total cholesterol levels; Increase in HDL cholesterol levels; Decrease in triglyceride levels; Slowing of the progression of coronary artery disease.

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